José V. Pardo, M.D., Ph.D.

Address

Cognitive Neuroimaging Unit (11P)
Psychiatry Service
VA Medical Center
One Veterans Drive
Minneapolis, MN 55417
Telephone: 612-725-2000, X2473
FAX: 612-725-2249
EMAIL: jvpardo@james.psych.umn.edu

Biosketch

B.S.; 1975; Chemistry & Physics; University of Miami; Coral Gables, FL
M.D./Ph.D.; 1983; Biochemistry, Cellular, and Molecular Biology Program;
Dept. Physiological Chemistry; Susan W. Craig, Ph.D., advisor; Johns Hopkins University; Baltimore, MD
Intern in Internal Medicine; 1984; Duke University Hospital; Durham, NC
Resident in Psychiatry; 1984-1987; Barnes Hospital; St. Louis, MO
Instructor in Psychiatry; 1988; Washington University School of Medicine; St. Louis, MO
Pfizer Fellow (1988-1990) in the laboratories of Marcus E. Raichle, M.D., and Michael I. Posner, Ph.D.; Washington University School of Medicine; St. Louis, MO
Assistant Professor in Psychiatry; 1989-1990; Washington University School of Medicine; St. Louis, MO
Assistant Professor in Psychiatry; 1991-1998; University of Minnesota School of Medicine; Minneapolis, MN
Director, Cognitive Neuroimaging Unit, 1991-present,VAMC, Minneapolis, MN
Associate Professor in Psychiatry, 1998-2004, University of Minnesota School of Medicine, Minneapolis, MN
Professor in Psychiatry, 2004-present, University of Minnesota School of Medicine, Minneapolis, MN

Research Interests

Cognitive neuroscience of higher cognitive functions and mental disorders
Neuroimaging of brain physiology
Application of high performance computing to biomedicine
Application of brain imaging to psychiatry and neurosurgery

Representative Publications

Pardo, J.V., Lee, J.T., Sheikh, S.A., Munch, K.R., Carlis, J.V., Lewis, S.M., Kuskowski, M.A., Disken, M.W. Where the brain grows old: Decline in anterior cingulate and medial prefrontal activity with normal aging. Neuroimage, in revision.
Stephan, M., Pardo, P.J., Hagen, M.C., Lee, J.T., Kuskowski, M.A., Pardo, J.V. About the mechanisms of auditory hallucinations: A positron emission tomographic study. J Psychiatry Neurosci, in press.
Faris, P.L., Eckert, E.D., Kim, S.W., Meller, W.H., Pardo, J.V., Goodale, R.L., Hartman, B.K. Evidence for vagal pathophysiology for for bulimia nervosa and the accompanying depressive symptoms. J Affect Disord 9279-90 (2006).
Pardo, J.V., Pardo, P.J., Humes, S.W., Posner, M.I. Neurocognitive dysfunction in antidepressant-free, non-elderly patients with unipolar depression: Alerting and the covert orienting of visuospatial attention. J Affect Disord 92:71-78 (2006).
Kilpatrick, L.A., Zald, D.H., Pardo, J.V., Cahill, L.F. Sex-related differences in amygdala functional connectivity during resting conditions. Neuroimage, in press (2006).
Laird, A.R., McMillan, K.M., Lancaster, J.L., Kochunov, P., Turkeltaub, P.E., Pardo, J.V., Fox, P.T. A comparison of label-based review and ALE meta-analysis in the Stroop task. Hum Brain Mapp 25:6-21 (2005).
Hurliman, E., Nagode, J.C., Pardo, J.V. Double dissociation of exteroceptive and interoceptive feedback systems in the orbital and ventromedial prefrontal cortex of humans. J Neurosci 25:4641-4648 (2005).
Zald, D.H., Curtis, C., Chernitsky, L.A., Pardo, J.V. Frontal lobe activation during object alternation acquisition. Neuropsychology 19:97-105 (2005).
Richter, H.O., Costello, P.A., Sponheim, S.R., Lee, J.T., Pardo, J.V. Funtional neuroanatomy of the human near/far response to blur cues: Eye-lens accommodation/vergence to point targets varying in depth. Eur J Neurosci 20:2722-2732 (2004).
Stephan, E., Pardo, J.V., Faris, P.L. Hartman, B.K. Kim, S.W., Ivanov, E.H., Goodale, R.L. Functional neuroimaging of gastric distension. J Gastrointest Surg 7:740-749 (2003).
Dichaut, J., McCabe, K., Nagode, J.C., Rustichini, A., Smith, K., Pardo, J.V. The impact of the certainty context on the process of choice. Proc Natl Acad Sci USA 100:3536-3541 (2003).
Hagen, M.C., Pardo, J.V. PET studies of somatosensory processing of light touch. Behav Brain Res 135:133-140 (2002).
Hagen, M.C., Franzen, O., McGlone, F., Dancer, C., Essick, G., Pardo, J.V. Tactile motion activates the human MT/V5 complex. Eur J Neurosci 16:957-964 (2002).
Hagen, M.C., Zald, D.H., Thornton, T.A., Pardo, J.V. Somatosensory processing in the human inferior prefrontal cortex. J Neurophysiol 88:1400-1406 (2002).
Zald, D.H., Pardo, J.V. The neural correlates of aversive auditory stimulation. Neuroimage 16:746-753 (2002).
Smith,K., Dickhaut, J., McCabe, K., Pardo, J.V. Neural correlates of choice under ambiguity, risk, gains, and losses. Management Science 48:182-189 (2002).
Zald, D.H., Curtis, C.E., Pardo, J.V. Prefrontal contributions to delayed spatial and object alternation: A PET study. Neuropsychology 16:182-189 (2002).
Nagode, J.C., Pardo, J.V. Human hippocampal activation during transitive inference. Neuroreport 13:939-944 (2002).
Zald, D.H., Madson, D.L., Pardo, J.V. Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect. Proc Natl Acad Sci USA 99:2450-2454 (2002).
Zald, D.H.,, Hagen, M.C., Pardo, J.V. Neural correlates of tasting concentrated quinine and sugar solutions. J Neurophysiol 87:1068-1075 (2002).
Curtis, C.E., Zald, D.H., Pardo, J.V. Organization of working memory within the human prefrontal cortex: A PET study of self-ordered working memory. Neuropsychologia 38:1503-1510 (2000).
Curtis, C.E., Zald, D.H., Lee, J.T., Pardo, J.V. Object and spatial alternation tasks with minimal delays activate the right anterior hippocampus proper in humans. Neuroreport 11:2203-2207 (2000).
Zald, D.H., Pardo, J.V. Cortical activation induced by intraoral stimulation with water in humans. Chem Senses 25:267-275 (2000).
Zald, D.H., Pardo, J.V. Functional neuroimaging of the olfactory system in humans. Int J Psychophysiol 36:165-181 (2000).

Pardo, P.J., Knesevich, M.A., Vogler, G.P., Pardo, J.V., Towne, B., Cloninger, C.R., Posner, M.I. Genetic and state variables of neurocognitive dysfunction in schizophrenia: A twin study. Schiz Bull 26:457-475 (2000).
Richter, H., Lee, J.T., Pardo, J.V. Neuroanatomical correlates of the near response: Voluntary modulation of accommodation/vergence in the human visual system. Eur J Neurosci 12:311-321 (2000).
Zald, D.H., Pardo, J.V. The functional anatomy of swallowing. Ann Neurol 46:281-286 (1999).

Kuskowski, M., Pardo, J.V. The role of the fusiform gyrus in successful encoding of face stimuli. Neuroimage 9:599-610, (1999).

Lorig, T.G., Elmes, D.L., Zald, D.H., Pardo, J.V. A computer-controlled olfactometer for fMRI and electrophysiological studies of olfaction. Behav Res Methods: Instru Comput 31: 370-375 (1999).
Small, D.M., Zald, D.H., Jones-Gotman, M., Zatorre, R.J., Pardo, J.V., Petrides, M. Human cortical gustatory areas. Neuroreport 10:1-8 (1999).
Le, T.H., Pardo, J.V., Hu,X. 4 T-FMRI study of non-spatial shifting of selective attention: Cerebellar and parietal contributions. J Neurophysiol 79:1535-1548 (1998).
Zald, D.H., Lee, J.T., Fluegel, K.W., Pardo, J.V. Aversive gustatory stimulation activates limbic circuits in humans. Brain 121:1143-1154 (1998).
Zald, D.H., Donndelinger, M.J., Pardo, J.V. Elucidating dynamic brain interactions with across-subjects correlational analyses of PET data: The functional connectivity of the amygdala and orbitofrontal cortex during olfactory tasks. J Cereb Blood Flow Metab 18:896-905 (1998).
Pardo, J.V., Wood, T.D., Costello, P.A., Pardo, P.J., Lee, J.T. PET study of the localization and laterality of lingual somatosensory processing. Neurosci Lett 234:23-26 (1997).
Zald, D.H. and Pardo, J.V. Emostion, olfaction, and the human amygdala: Amygdalar activation during aversive olfactory stimulation. Proc Natl Acad Sci USA 94:4119-4124 (1997).
Claypool, M.L., Riedl, J., Carlis, J.V., Wilcox, G., Elde, R., Retzel, E., Georgopoulus, A.P., Pardo, J.V., Ugurbil, K., Miller, B.N., Honda, C.N. Network requirements for 3D flying in a zoomable brain database. IEEE ISAC 13:816-827 (1995).
Raichle, M.E., Fiesz, J., Videen, T.O., MacLeod, A.K., Pardo, J.V., Fox, P.T., Petersen, S.E. Practice-related changes in human brain functional anatomy during non-motor learning. Cerebral Cortex 4:8-26(1994).
Pardo, J.V., and Fox, P.T. Preoperative assessment of the cerebral hemispheric dominance for language with CBF PET. Human Brain Mapping 1:57-68 (1993).
Pardo, J.V., Pardo, P.J., Raichle, M.E. Neural correlates of human self-induced dysphoria. Am J Psychiatry 150:713-719 (1993).
Fox, P.T., and Pardo, J.V. Does inter-subject variability in cortical functional organization increase with neural "distance" from the periphery? Ciba Symposia 163:125-144 (1991).
Janer, K.W., and Pardo, J.V. Selective attention deficits following bilateral anterior cingulotomy. J Cogn Neuroscience 3:231-141 (1991).
Pardo, J.V., Fox, P.T., and Raichle, M.E. Localization of a human system for sustained attention by positron emission tomography. Nature 349:61-64(1991).
Pardo, J.V., Pardo, P.J., Janer, K.W., and Raichle, M.E. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci USA 87:256-259 (1990).
Pardo, J.V., Pittenger, M.F., and Craig, S.W. Subcellular sorting of isoactins: Selective association of gamma-actin with skeletal muscle mitochondria. Cell 32:1092-1103 (1983).
Pardo, J.V., D'Angelo Siliciano, J., and Craig, S.W. A vinculin-containing cortical lattice in skeletal muscle: Transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma. Proc Natl Acad Sci USA 80:1009-1012 (1983).
Pardo, J.V., D'Angelo Siliciano, J., and Craig, S.W. Vinculin is a component of an extensive network of myofibril-sarcolemma attachment regions in cardiac muscle fibers. J Cell Biol 97:1081-1088 (1983).
Craig, S.W., and Pardo, J.V. Gamma actin, spectrin, and intermediate filament proteins colocalize with vinculin at costrameres, myofibril to sarcolemmal attachment sites. Cell Motil 3:449-562 (1983).
Craig, S.W., and Pardo, J.V. Alpha-actin localization in the junctional complex of intestinal epithelium. J Cell Biol 80:203-210 (1979).
Pardo, J.V., Crese, I., Burt, D.R., and Snyder, S.H. Ontogenesis of dopamine receptor binding in the corpus striatum of the rat. Brain Res 125:376-382 (1977).

José V. Pardo, M.D., Ph.D.
Cognitive Neuroimaging Unit(11P)
VA Medical Center
One Veterans Drive
Minneapolis, MN 55417

jvpardo@james.psych.umn.edu